By Paul M. Wassarman (Eds.)
The inaugural quantity of Advances in Developmental Biology and Biochemistry paints a slightly huge stroke during the box. development formation and mobile verbal exchange in the course of animal improvement, in addition to Y chromosome functionality in the course of mammalian improvement, are significant subject matters of this quantity. a number of experimental platforms, together with mice, flies, and worms are thought of.
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G.. Frey, A. Z.. Gash. D. J . , Chow. E. P.. Fisher, R. A.. Benonis. J. M . Torres. G . , Wallner. 6 . P.. Ramachandran, K. L.. Ragin. R. C.. Manganaro. T. F.. MacLaughlin. D. T.. and Donahoe. P. K. (1986) Isolation o f the bovine and human genes for Miillerian inhibiting substance and expression o f the human gene in animal cells. Cell 45:685498. Cattanach. B. M. (1987) Sex-reversed mice and sex determination. Ann. Y. Acad. Sci. 51327- 29. Cattanach. B. M . Evans, E. , Burtenshaw. M.. and Barlow.
The floor plate is clearly a local source of retinoic acid (Wagner et al.. 1990). a substance implicated in pattern regulation in the vertebrate limb. It is tempting to speculate that Wnr-I might play some role in establishment of dorsal-ventral polarity. Similarly, localized expression of Wnr- I within the region of the open neural plate that is destined to give rise to the midbrain and dorsal rostral hindbrain suggests that Wnr- I may have some part in the patterning of the early brain. As will be apparent in the final section, this conjecture is supported by the analysis of Wnr- I null mutants in the mouse.
At the extended germ band stage, DWnr-r17 is expressed in all parasegments; however, unlike wg. expression is localized not to a continuous band throughout the parasegment but is restricted to two discrete regions. At the lateral margins of the embryo, which later form the dorsal midline after dorsal closure, transcripts are localized in the anterior of each parasegment. In addition, expression is detected in paired groups of two to a few cells, probably neuroblasts. distributed either side of the central midline.
A Research Annual by Paul M. Wassarman (Eds.)